Prognosis and Influencing Factors of Patients with Myeloperoxidase-Anti-Neutrophil Cytoplasmic Antibody Associated Vasculitis
LI Yubao
LIU Yamin
LU Xiaoqing
QIAO Yingjin
WANG Pei
Abstract：Objective To explore the prognosis(patients survival,renal survival)and its influencing factors of myeloperoxidase-anti-neutrophil cytoplasmic antibody(ANCA)-associated vasculitis patients.Methods A total of 58 consecutive patients with MPO-ANCA-associated vasculitis(AAV)diagnosed in the First Affiliated Hospital of Zhengzhou University from January 2020 to December 2020 were recruited.Follow up till 1 st May,2022 or till the happen of outcome event[dead or in maintenance hemodialysis(MHD)].The clinical data of the patients were collected,and the prognosis for patients survival and renal survival were retrospectively analyzed by univariate analysis and multivariate analysis.Results Till the end of the follow up,there were 44(75.9％)patients alive.The results of multivariate Cox regression analysis showed that age≥70 years old,Birmingham vasculitis activity scale(BVAS)score ≥20 points,and serum creatinine(Scr)level ≥353.6 µmol·L-1and blood purification therapy were independent influencing factors for patient survival and prognosis(P＜0.05).There were 25 patients(43.1％)eventually entered MHD,and multivariate logistic regression analysis showed that kidney biopsy and Scr level≥353.6 μmol·L-1,urine red blood cell count≥20 μL-1 were the independent influencing factors for renal prognosis in patients.Conclusion Age,BVAS score,Scr level,and blood purification therapy are factors that affect the survival and prognosis of MPO-AAV patients.Scr levels,urinary red blood cell count,and renal biopsy are factors that affect patients entering MHD.
Keywords：vasculitismyeloperoxidase-anti-neutrophil cytoplasmic antibodyprognosis of patients survivalprognosis of renal survival
Publication Date：2023-11-30
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：6( 4051-4056 )