Mechanism of Dihydroartemisinin Treat Sjögren Syndrome Based on Network Pharmacology and Molecular Docking
LIU Ruilin
LI Jigao
DU Mingrui
ZHOU Quan
Abstract：Objective To explore the potential molecular mechanism of dihydroartemisinin(DHA)for the treatment of Sjögren syndrome(SS)through network pharmacology and molecular docking techniques.Methods Intersecting targets of DHA and SS were obtained from PubChem,GeneCards,OMIM and TTD databases,protein-protein interaction(PPI)network analysis was constructed by STRING database and Cytoscape 3.8.2,GO functional enrichment and KEGG pathway enrichment were performed using DAVID database,AutoDock Vina was used to perform molecular docking of DHA and SS key targets.Results A total of 31 intersecting targets and 12 core targets including EGFR,ERBB2,CASP1 and MMP9 were screened,and the molecular docking results showed that DHA had good binding activity to EGFR,CASP1 and MMP9.Combined with KEGG and GO analysis,which is maybe to affect SS cell aberrant apoptosis and immune inflammatory response through necroptosis,endocrine resistance pathway.Conclusion DHA may play a role in the treatment of SS by regulating abnormal apoptosis and reducing the immune inflammatory response through a"multi-target-multi-pathway"approach.
Keywords：Sjögren syndromenetwork pharmacologymolecular dockingdihydroartemisinin
Publication Date：2023-11-30
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：7( 4037-4043 )