Effects of low frequency repetitive transcranial magnetic stimulation on learning and memory and synaptic plasticity in hippocampus of vascular cognitive impairment rats
Wang Hongwei
Liu Baojun
Mao Xijiang
Wang Changquan
Tu Qiang
Huang Yi
Lu Chengbiao
Abstract：Objective To study the effect of low frequency repetitive transcranial magnetic stimulation (rTMS) on learning and memory and the long-term potentiation (LTP) in hippocampus of vascular cognitive impairment(VCI) rats.Methods Sixty male SD rats were randomly divided into normal group, sham-operated group, model group(VCI), control treatment group(VCI+ rTMS).The spatial learning and memory ability of rats was measured by Morris water maze.Electrophysiological recordings were conducted to detect the effects of repetitive transcranial magnetic stimulation(rTMS)on phenomena of synaptic transmission long-term LTP in dentate gyrus (DG) of hippocampus slices under the high frequency stimulation (HFS).Results In the escape latency after the 4th days, the rTMS treatment group was shortened to the model group (P<0.05).10 minutes later, the PS amplitude of the control treatment group increased and the LTP was enhanced, there were significant difference compared with model group(P<0.01).Conclusion The rTMS can improve VCI model rats learning and memory ablity by means of enhancing hippocampal LTP and the function of synaptic plasticity.
Keywords：repetitive transcranial magnetic stimulationvascular cognitive impairmenthippocampuslearning and memorylong-term potentiation
Publication Date：2017-01-01
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：3( 1350-1352 )