The relationship between neoadjuvant chemotherapy and the expression levels of ER, PR,Her-2 and Ki-67 in breast cancer
Cao Wujie
Su Jing
Cai Ming
Abstract：Objective To investigate the relationship between neoadjuvant chemotherapy and the expression levels of ER, PR, Her-2 and Ki-67 in breast cancer.Methods Seventy-six patients with breast cancer treated in the First Affiliated Hospital of Zhengzhou University from September of 2014 to September of 2015 were selected.The expression levels of ER, PR, Her-2 and Ki-67 before and after neoadjuvant chemotherapy were detected.The relationship between neoadjuvant chemotherapy and the expression levels of ER, PR, Her-2 and Ki-67 was analyzed.Results The total effective rates of patients with ER (-), PR (-), Ki-67(+) were higher than patients with ER (+), PR (+), Ki-67(-) (P＜0.05).There was no difference in the positive rates of ER, PR, Her-2 before and after neoadjuvant chemotherapy (P＞0.05).The positive rate of Ki-67 after neoadjuvant chemotherapy was lower than that before neoadjuvant chemotherapy, and the difference was statistically significant (P＜0.05).Conclusion Breast cancer patients with ER (-), PR (-), Ki-67 (+) can obtain a higher clinical therapeutic effect of neoadjuvant chemotherapy.After neoadjuvant chemotherapy, there was no change in the expression levels of ER, PR, Her-2 except Ki-67.
Keywords：breast cancerneoadjuvant chemotherapyTAC schemeestrogen receptorprogesterone receptorhuman epidermal growth factor receptor 2Ki-67
Publication Date：2017-01-01
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：4( 985-988 )