Predictive factors of pathological complete response after TAC neoadjuvant chemotherapy for breast cancer in young women
Zhang Anran
Gao Yanli
Li Mengquan
Abstract：Objective To analyze the predictive factors of pathological complete response (pCR) after TAC neoadjuvant chemotherapy (docetaxel+epirubicin/pirarubicin+cyclophosphamide) for breast cancer in young women.Methods From January of 2011 to July of 2016, 248 young breast cancer patients (age＜40 years) treated with TAC neoadjuvant chemotherapy were included in this retrospective study.pCR rate was recorded.The influence factors of pCR were analyzed using Chi-square and logistics analysis.Results pCR was detected in 53 patients (53/248, 21.4％).In univariate analysis, we found BMI, BSA, clinical stage, Ki-67, tumor types and ER were correlated with pCR.TNBC (OR=46.3, 95％ CI=1.046-18.474), Ki-67 (+) (OR=8.201, 95％ CI=1.970-34.135), clinic stage Ⅱ(OR=5.011,95％ CI=1.626-20.498), and BMI＜24 kg/m2 (OR=3.179,95％ CI=1.022-9.855) were considered as independent prognostic factors in multivariate analysis.Conclusion In young breast cancer patients, TNBC,Ki-67(+), BMI＜24 kg/m2 and clinical stageⅡ are significantly corrected with pCR.
Keywords：breast cancerimmunohistochemistryneoadjuvant chemotherapypathological complete responsebody mass indextriple negative breast cancer
Publication Date：2017-01-01
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：4( 982-985 )