Prognostic factors of thrombosis in patients with cervical cancer
Cheng Weiwei
Liu Zheyan
Li Xue
Liu Xinjian
Song Yongping
Abstract：Objective To investigate the influence of coagulation-based risk factors on the prognosis of cervical cancer and to analyze the prognostic factors.Methods The clinical data of cervical cancer patients from June of 2014 to June of 2016 were analyzed by SPSS 22.0 statistical software.Kaplan-Meier method was used to calculate the survival rate of patients with cervical cancer.The survival difference of each group was compared by the Log-rank method, and the multivariate prognostic analysis was performed in the Cox model.Results A total of 412 patients were enrolled in this study, including 47 patients with thrombosis and 365 non-thrombotic patients.The mortality rate of non-thrombotic patients was higher than thrombotic patients (P=0.002<0.001).Univariate analysis showed that tumor stage(P<0.001), Khorana score (P=0.010), D-dimer (P<0.001) and APTT (P<0.001) were related to the prognosis of cervical cancer patients.Multivariate regression analysis showed that tumor stage, Khorana score, D-dimer and APTT were independent prognostic factors.D-dimer(P<0.001), APTT (P<0.001), and SCC (P=0.032) in the death group were significantly higher than the survival group.Conclusion The prognosis of cervical cancer patients accompanied by deep vein thrombosis is poor, which may be related to high level of D-dimer, high level of APTT and high Khorana score.
Keywords：D-dimercervical cancerdeep vein thrombosisKhorana score
Publication Date：2017-01-01
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：4( 769-772 )