Distribution and drug resistance of pathogenic bacteria causing urinary tract infection in patients with type 2 diabetes in Henan
Wang Yanyan
Yue Xiao
Yang Yang
Wang Zhimin
Sun Liangge
Abstract：Objective To analyze the distribution and drug resistance of pathogenic bacteria causing urinary tract infection in patients with type 2 diabetes in Henan, and offer the scientific evidences for reasonable use of antibiotics and correct diagnosis of this diseases in patients with type 2 diabetics.Methods The data of 772 patients with type 2 diabetes treated in the First Affiliated Hospital of Zhengzhou University from January 1st of 2012 to October 31st of 2015 were retrospectively analyzed for having a good knowledge of the distribution and drug resistance of pathogenic bacteria causing urinary tract infection.Results 213 strains of pathogens were isolated from 772 urine specimens and the positive rate was 27.60%.121 (56.81%) Gram-negative cocci were isolated and the top 1 was Escherichia coli (38.03%).There were 62 strains (76.54%) were ESBLs-producing in Escherichia coli.There were 14 strains (87.50%) were ESBLs-producing in Klebsiella pneumoniae.63 strains (29.58%) of Gram-positive cocci were isolated and the top 1 was Enterococcus faecalis (9.86%).29 strains (13.61%) of fungus were isolated.Imipenem was the most sensitive to Escherichia coli, followed by amikacin and piperacillin/tazobactam.Resistance rates of Escherichia coli to ampicillin, cefazolin, levofloxacin were higher.Imipenem was the most sensitive to Klebsiella pneumoniae, followed by piperacillin/tazobactam, cefepime, amikacin.Resistance rates of Klebsiella pneumoniae to ampicillin, cefazolin, ceftriaxone were higher.Vancomycin, teicoplanin and linezolid were more sensitive to Enterococcus faecalis, and the resistance rates of Enterococcus faecalis to erythromycin, high concentration of gentamicin and high concentration of streptomycin.The sensitivities of Enterococcus to linezolid, vancomycin, teicoplanin was 100%.Conclusion Gram-negative bacillus is the main pathogenic bacteria causing urinary tract infection in patients with type 2 diabetes.High proportions of Escherichia coli and Klebsiella pneumoniae are ESBLs-producing strains.The common pathogenic bacteria are resistant to antibiotics in different degree.
Keywords：type 2 diabetesurinary tract infectionpathogenic bacteriadrug resistancesensitivity
Publication Date：2017-01-01
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：4( 583-586 )