Correlation between the characteristics of recurrence, metastasis and molecular subtypes of breast cancer
Zhang Ying
Xu Bin
Liu Hui
Shao Yingbo
Chen Qi
Liu Chaojun
He Yaning
Abstract：Objective To explore the correlation between the characteristics of recurrence, metastasis and molecular subtypes of breast cancer, and to provide a theoretical basis for the treatment of recurrent and metastatic of breast cancer and predict prognosis.Methods The clinical data of 190 patients with recurrent and metastatic breast cancer were retrospectively analyzed.The correlation between the characteristics of recurrence, metastasis (including diseased region, lesion number, aberration rate and survival rate) and molecular subtypes of breast cancer was statistically analyzed.Results The breast cancer of Luminal type was prone to bone metastasis (P<0.001), and HER-2 enrich and triple-negative breast cancer was prone to visceral metastasis (P<0.05).HER-2 enrich and triple-negative breast cancer were prone to multiple metastases, but the difference was not statistically significant (P>0.05).The aberration rate of Luminal A was the highest, and the aberration rate of HER-2 enrich was the lowest, and the difference was statistically significant (P<0.05).Prognostic analysis showed that there was no statistical difference in progression-free survival among different molecular subtypes of advanced breast cancer (P>0.05).Conclusion The recurrence and metastasis of breast cancer is closely related to the molecular subtypes of primary foci.Molecular subtype can be used as a basis for predicting the prognosis of patients.
Keywords：molecular subtypebreast cancerrecurrencemetastasis
Publication Date：2017-01-01
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：4( 395-398 )