The anti-inflammatory effect of Clarithromycin on COPD rats
Sun Panfeng
Huang Shifu
Miao Lijun
Huang Fengxiang
Zhao Di
Peng Qiang
Abstract：Objective To investigate the anti-inflammatory effect of clarithromycin on chronic obstructive pulmonary diseases (COPD) rats and the improvement of pulmonary function.Methods COPD rat model was established.Rats were randomly divided into 3 groups: control group, COPD group and clarithromycin group, 10 rats in each group.After the experiment, the pulmonary function of rats was determinated, and the serum and alveolar lavage fluid was collected for detecting the levels of INF-γ, TNF-α, NF-κB.Results Compared with control group, the expiratory forced capacity volume 0.3/forced vital capacity (FEV0.3/FVC), resistance inspiratory (Ri) and resistance expiratory (Re) in the COPD group were significantly lower than blank group, and the differences were statistically significant (P<0.05).Compared with COPD group, FEV0.3/FVC, Ri and Re in the clarithromycin group were higher than group COPD, and the differences were statistically significant (P<0.05).In COPD group, INF-γ,TNF-α,NF-κB level in serum and alveolar lavage fluid were higher than those in the blank group, and the differences were statistically significant (P<0.05).In clarithromycin group, the levels of INF-γ, TNF-α, NF-κB in serum and alveolar lavage fluid were lower than group COPD, and the differences were statistically significant (P<0.05).Conclusion Clarithromycin can reduce the pulmonary and systemic inflammation in COPD rat to a certain extent, and improve the pulmonary function.
Keywords：clarithromycinchronic obstructive pulmonary diseasesinflammationpulmonary function
Publication Date：2017-01-31
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：3( 390-392 )