Diagnosis and treatment analysis of pancreatoblastoma in 6 children
He Wei
Wang Jiaxiang
Yang Heying
Zhang Da
Yang Lin
Abstract：Objective To further learn about pediatric pancreatoblastoma (PBL) by investigating its clinical features, diagnosis and treatment methods and the recent prognosis, etc.Methods A retrospective review of pediatric PBL cases was undertaken within 6 years in the First Affiliated Hospital of Zhengzhou University.Results Six cases of pediatric PBL, 3 males, 3 females, age range was 2 years old to 7 years old, mean age was 5 years old.There were 6 cases of abdominal mass, 3 cases of abdominal pain, 1 case of jaundice, 1 case of anemia, 1 case of vomiting.The maximum diameters of the tumors ranged from 30 mm to 160 mm, and the average diameter was 87 mm.Two cases located in the pancreatic head, 3 cases at the end of the pancreatic body, 1 case in pancreatic tail.The immunohistochemical results: 6 cases of Syn (+) or (range+), 6 cases of CK (+), 5 cases of AAT (+), Ki-67 (>30%+), 3 cases of CD56 (+) or (range+), 5 cases of AFP (-), 1 cases of AFP (range+).One patient refused chemotherapy after operation and five patients received chemotherapy.The follow-up period was 11 months to 37 months.Two patients were lost to follow-up.Three patients died.One patient was alive.Conclusion PBL is a rare malignant tumor, more common in children.The various parts of the pancreas can grow.Because of the high degree of malignancy of the tumor, so its recurrence rate and mortality are high.The preferred treatment regimen is a complete resection of the tumor, followed by chemotherapy.Some patients can survive for a long time after complete resection with chemotherapy.
Keywords：pancreatoblastomachilddiagnosis and treatmentimmunohistochemical stainingsurvival
Publication Date：2017-01-01
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：4( 386-389 )