The effect observation on noninvasive positive pressure ventilation combined with respiratory stimulant in the treatment of chronic obstructive pulmonary respiratory failure combined with pulmonary encephalopathy
Hu Bin
Abstract：Objective To investigate the therapeutic effect of noninvasive positive pressure ventilation combined with respira-tory stimulant in the treatment of chronic obstructive pulmonary respiratory failure and pulmonary encephalopathy.Methods 104 patients with chronic obstructive pulmonary respiratory failure and pulmonary encephalopathy were randomly divided into the con-trol group and the observation group,52 cases in each group.The control group was treated with conventional therapy,the obser-vation group was treated with noninvasive positive pressure ventilation combined with respiratory stimulant therapy.Arterial oxy-gen partial pressure (PaO2 ),arterial oxygen saturation (SpO2 ),pH,heart rate (HR),respiratory rate (RR)before and after treatment were compared between two groups.The therapeutic effect was evaluated according to treatment improvement condition. Results The improvement of HR,RR,PaO2 ,SpO2 ,PaCO2 and pH in the observation group were significantly higher than those in the control group before and after treatment (P<0.05 ).The effective rate in the observation group was significantly higher than that in the control group,with a lower mortality rate and shorter hospitalization time,and the differences were statisti-cally significant (P<0.05).Conclusion The effect of noninvasive positive pressure ventilation combined with respiratory stim-ulant in the treatment of chronic obstructive pulmonary disease with pulmonary encephalopathy is effective.It can improve the re-spiratory function and the prognosis of patients,promote the healing of the disease,reduce the rate of endotracheal intubation and mortality,and has clinical feasibility.
Keywords：noninvasive positive pressure ventilationrespiratory stimulantschronic obstructive pulmonary respiratory fail-urepulmonary encephalopathy
Publication Date：2016-01-01
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：3( 2138-2140 )