The early diagnostic value of serum cystatin C and homocysteine in patients with type 2 diabetic nephropathy
Yang Yanli
Abstract：Objective To explore the early diagnostic value of serum cystatin C(Cys C)and homocysteine(Hcy)in patients with type 2 diabetic nephropathy(DN).Methods A total of 1 14 patients with type 2 diabetic mellitus in Xiangcheng People’s Hospital from May of 2014 to April of 2015 were selected.According to urinary albumin excretion rate (UAER),all patients were divided into simple diabetic mellitus group (DMgroup,n=47)and early diabetic nephropathy group (DN group,n=67). 60 healthy subjects of the same period determined by physical examination were enrolled as control groups.Serum Cys C,Hcy, blood urea nitrogen (BUN)and serum creatinine (Scr)were measured and compared.Results The serum levels of Cys C,Hcy in DM group was higher than those in DM group and control group,and there were statistical difference(P<0. 05 ).There was no significant difference in serum levels of Cys C,Hcy between DM group and control group(P>0. 05 ).The positive rate of Cys C,Hcy in DN group were 64.18%and 49.25%,significant higher than Scr and BUN.Conclusion The serum Cys C and Hcy can reflect early renal injury,and can be used as early diagnosis in type 2 diabetic nephropathy.
Keywords：cystatin Chomocysteinediabetic nephropathy
Publication Date：2016-01-01
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：3( 1936-1938 )