The correlation between plasma brain natriuretic peptide (BNP)levels and parameters of pulse -indicated continuous cardiac output(PiCCO)in patients with septic shock
Wu Xiang
Tao Fei
Hu Guifang
Deng Liehua
Yao Huaguo
Abstract：Objective To investigate the relationship between plasma brain natriuretic peptide (BNP)levels and the monito-ring indicators of pulse -indicated continuous cardiac output (PiCCO)in patients with sepstic shock.Methods 48 patients with septic shock according to the criteria of sepsis set by SC-CN /ESICM/ACCP /ATS /SIS were selected.Clinical and laboratory data including BNP were collected on the 1 d,3rd and 5 th day after admittion.The hemodynamics of the patients was monitored using PiCCO technology,and the heart function indexs were recorded,incluing CI,CFI,GEF and dP /dPmax.Acute Physiology and Chronic Health Evaluation (APACHEⅡ)and Sepsis -related Organ Failure Assessment (SOFA)score were determined.The correlation between BNP levels and the above indexs was analyzed.Results The levels of plasma BNP had negative correlation with CI,CFI,GEF (r =-0.339, -0.250, -0.241 ,P <0.05 ),and had no significant correlation with dP /dPmax (P >0.05 ).The levels of plasma BNP had significant positive correlation with APACHEII scores and SOFA scores (r =0.509,0.565 ,P <0.05 ). Conclusion The cardiac function could not be reflected by BNP levels in septic shock patients.Plasma BNP levels can re-flect the severity of septic shock in certain degree,and might be considered as a valuable prognostic factor for patients with septic shock.
Keywords：septic shockbrain natriuretic peptidepulse -indicated continous cardiac output
Publication Date：2016-01-01
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：4( 1553-1556 )