Current status of clinical use of antibacterial drugs for inpatients and bacterial resistance in a cancer hospital
Lin Xiaozhen
Zhang Wenzhou
Zhao Xiuli
Wang Weiguo
Wang Sujuan
Abstract：Objective To investigate the application of antibacterial drugs and the drug resistance of clinical isolates from cancer hospital in 201 3,so as to provide useful information for rational use of drugs.Methods Data were collected from a third -grade class -A cancer hospital in 201 3.The statistical analysis of antibacterial drugs was performed.Antimicrobial sus-ceptibility testing of clinical isolates was carried out by means of MIC and results were analyzed according to CLSL.Results The utilization ratio of antibacterial drugs for the inpatients was 24.44%.Per capita expenses was calculated at ￥1 878.91 .The mean number of antibiotic consumption was 1 .87 per capita.Autibiotics use density(AUD)was 1 5.60 DDDs per one hundred people.The proportion of the top 3 drug varieties of consumption sum were cephalosporins 48.29%,triazoles 1 6.27% and quino-lones 6.79%.The DDDs proportion of prophylactic agents (as cefazolin,cefuroxime and Ceftriaxone)was 28.26%.A total of 4 81 0 clinical isolates were collected from January to December in 201 3,of which E.coli and K.pneumoniae accouted for 23.7%and 1 1 .8%.The prevalence of methicillin -resistant strains in S.aureus (MRSA)and coagulase negative staphylococcus (MRCNS)was 1 1 .9% and 63.1 % respectively.The prevalence of ESBLs producing strains was 75.8% in E.coli and 47.0%in K.pneumoniae and 51 .0% in K.oxytoca.Conclusion Hospital overall index of clinical application of antibacterial drugs is reasonable.There is a relation between some bacterial resistance rates and DDDs of antimicrobials.
Keywords：cancer hospitalantibacterial drugsfrequency of drug usebacterial resistane
Publication Date：2016-01-01
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：4( 1547-1550 )