The correlation between spectral CT parameters and perfusion parameters in rabbit liver tumor model
Yan Xiaopeng
Yang Xuehua
Lv Peijie
Chai Yaru
Abstract：Objective To assess the correlation between spectral CT parameters and perfusion parameters in rabbit VX2 liver tumor model.Methods 24 rabbits with VX2 liver tumor underwent GSI perfusion one -stop CT scan to generate spectral images and perfusion images.The enhanced borders of tumors were stained immunohistochemically with CD34,MVD was shown by anti -CD34.The correlation of iodine concentration of tumor with perfusion parameters and MVD were analyzed by using Pear-son’s correlation analysis.Results The tumor iodine based in value of arterial phase had an positive correlation with BV,BF, HAF,PS and MVD(all P <0.05),and had a negative correlation with MTT(P <0.05).The tumor iodine based value of venous phase had an positive correlation with BV,BF,PS and MVD (all P <0.05),and had no correlation with HAF,MTT.Conclusion The tumor iodine based value obtained from spectral CT images corre-lates strongly with perfusion parameters and MVD,which can reflect tumor blood supply changes.
Keywords：tomographyX -ray computedVX2 liver tumorrabbitperfusioncorrelation
Publication Date：2016-01-01
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：4( 1347-1350 )