Diagnostic value of the plasma HOXA13 protein for hepatocellular carcinoma
Chen Mingkai
Zhang Siyu
Yang Yuxiu
Abstract：Objective To explore the diagnostic value of the plasma HOXA13 protein for hepatocellular carcinoma.Methods The research objects were divided into hepatocellular carcinoma group (n =62),liver cirrhosis group (n =30)and healthy con-trol group (n =30),including patients and healthy people from March 1,2014 to December 30,2014 in People’s Hospital of Zhengzhou University.Plasma HOXA13 protein and α-fetoprotein (AFP)levels of research objects were measured by enzyme -linked immunosorbent assay (ELISA).Results The average of the plasma HOXA13 protein expression in HCC [(715.42 ± 352.31)pg/ml]was significantly higher than that of liver cirrhosis group [(265.58 ±159.27)pg/ml]and healthy control group [(215.50 ±120.93)pg/ml](P <0.05).When combining AFP and HOXA13 protein,greater sensitivity of HCC(88.7%) could be achieved than HOXA13 protein(71.0%)or AFP(61.3%),respectively.Conclusion Plasma HOXA13 protein may have important value in the diagnosis of HCC.The combination of HOXA13 and AFP could improve the sensitivity of HCC.
Keywords：hepatocellular carcinomaplasmaHOXA13α-fetoproteinenzyme -linked immunosorbent assay
Publication Date：2016-01-01
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：3( 974-976 )