The efficacy of different doses of dexmedetomidine combined with sufentanil on postoperative analgesia in children undergoing hypospadias operation
Sun Zhentao
Cao Yanan
Wang Ning
Sun Xueqing
Han Xueping
Zhang Wei
Yang Chunyao
Abstract：Objective To observe the efficacy of different doses of dexmedetomidine (Dex)combined with sufentanil on post-operative analgesia in children undergoing hypospadias operation.Methods 80 cases of children undergoing the elective hypospa-dias operation were randomly divided into 4 groups,20 cases in each group:group C received sufentanil 0.04 μg/(kg·h),group D1 received sufentanil 0.04 μg/(kg·h) +Dex 0.02 μg/(kg·h),group D2 received sufentanil 0.04 μg/(kg·h) + Dex 0.04 μg/(kg·h),group D3 received sufentanil 0.04 μg/(kg·h) +Dex 0.06 μg/(kg·h).4 groups used the same induc-tion and maintenance of anesthesia.Intravenous injection of sufentanil with 0.15 μg/kg was conducted at 30 min before the end of operation.The patient -controlled intravenous analgesia (PCIA)at the end of operation was immediately jointed.The non -invasive blood pressure,heart rate,SpO2 ,the score of faces pain scale (FPS)and Ramsay sedation of children at 2,4,8,12, 24 and 48 h after operation were recorded,and the press number of PCIA and the incidence of side effects were recorded.Re-sults Compared with group C,at each time point,FPS scores in group D1 ,D2 and D3 were lower (P <0.05),and they were lower in group D2 and D3 than in group D1 (P <0.05);Ramsay sedation scores were higher in group D1 ,D2 and D3 than in group C at all the time points (P <0.05),and they were positively correlated with Dex dose in 4 hours (P <0.05);Compared with group C and D1 ,the press number of PCIA and the incidence of nausea and vomiting in group D2 and D3 declined (P <0.05),but there were 2 cases of excessive sedation in group D3 .No bradycardia,hypotension and respiratory depression hap-pened in 4 groups.Conclusion In postoperative analgesia for children with hypospadias,Dex could enhance the effect of analge-sia and reduce side effects,but it needs to prevent excessive sedation.The dose of 0.04 μg/(kg·h)is the best selection.
Keywords：dexmedetomidinesufentanilpatient -controlled intravenous analgesiachildren hypospadias operation
Publication Date：2016-01-01
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：3( 795-797 )