Influence of the 2013 ASCO/CAP HER2 guideline updates on HER2 FISH testing on breast cancer
Du Xianjuan
Shen Jingwei
Abstract：Objective To compare the influence of 2007 and 2013 ASCO/ CAP HER2 guideline on HER2 FISH testing on breast cancer. Methods We reviewed the 115 HER2 fluorescence in situ hybridization( FISH)results of before the HER2 guidelines updates and classified them according to both the 2007 and 2013 guidelines as negative,positive,or equivocal. Re-sults Of 115 HER2 FISH results,53(46. 1% )were positive,58(50. 4% )were negative and 4(3. 5% )were equivocal when reassessed by 2007 guidelines. Of 115 HER2 FISH results,55(47. 8% )were positive,53(46. 1% )were negative and 7(6. 1% )were equivocal when reassessed by 2013 guidelines. There was a significant increase in the number of HER2 FISH e-quivocal results after the guideline updates(6. 1% vs 3. 5% ,P ﹤ 0. 001). Conclusion Implementation of the 2013 ASCO/CAP HER2 guideline updates resulted in an increase in HER2 FISH equivocal results,which can be attributed to HER2 copy number,regardless of the HER2 / CEP17 ratio.
Keywords：human epidermal growth factor receptor 2fluorescence in situ hybridizationbreast cancerASCO/ CAP HER2 guideline
Publication Date：2016-01-01
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：3( 608-610 )