Protective function of reducing glutathione on airway epithelial cells in guinea pig models of asthma
Zhang Yun
Zhang Tieshuan
Han Li
Abstract：Objective To study the protective function of reducing glutathione on airway epithelial cells in guinea pig models of asthma. Methods Forty guinea pigs were randomly divided into 4 groups:control group,asthma group,reducing glutathione group and dexamethasone group,10 guinea pigs in each group. INF - r level in bronchoalveolar lavage fluid was detected by en-zyme linked immunosorbent assay. TUNEL was used to detect the level of epithelial cells and RT - PCR was used to determine the status of Bcl - 2mRNA in lung tissue. Results Compared with asthma group,the INF - r levels in bronchoalveolar lavage fluid of reducing glutathione group were statistically higher( P ﹤0. 05),similar with that in the dexamethasone group(P ﹥ 0. 05). The levels of T - AOC and Bcl - 2 mRNA in lung tissue of re-ducing glutathione group were significantly upper compared with asthma group(P ﹤ 0. 05). Conclusion Reducing glutathione have the ability to protect airway epithelium in guinea pig models of asthma.
Keywords：asthmareducing glutathioneapoptosis
Publication Date：2016-01-01
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：4( 593-596 )