The dynamic changes of TBIL、WBC、HGB、PT、PTA、INR of HBV -associated acute -on -chronic liver failure
Yin Pengbo
Zeng Qinglei
Li Jingjing
Yang Kangli
He Yuting
Yu Zujiang
Abstract：Objective To investigate the dynamic changes of total bilirubin (TBIL),white blood cells (WBC),hemoglobin (HGB),prothrombin time (PT),prothrombin time activity (PTA),international standard value(INR)of the HBV -associated acute -on -chronic liver failure (HBV -ACLF).Methods 86 patients with HBV -ACLF were enrolled and divided into im-provement group and deterioration group according to their prognosis at 4 weeks after admission.All patients were administered with the same regimen.And then the dynamic changes of TBIL、WBC、HGB、PT、PTA、INR and its predictive value on prognosis were analyzed.Results TBIL in improvement group increased to peak at week 1 after admission and then declined gradually through week 4,while TBIL in deterioration group increased consistently.Serum TBIL levels in deterioration group were higher than the improvement group(P <0.05).WBC in both groups declined gradually during the four -weeks observational period after admission.WBC levels in deterioration group was higher than the improvement group(P <0.05).However,the week 3 was ex-cluded.HGB in both groups declined gradually during the four -week observational period after admission.No statistical differ-ence was observed for HGB level in both groups(P >0.05).PT and INR in deterioration group increased gradually while de-clined in improvement group during the four -week observational period after admission.PT and INR levels in deterioration group was higher than the improvement group during the four -week observational period after admission (P <0.05).PTA in deterio-ration group declined gradually while elevated in improvement group during the four -week observational period after admission.PTA levels in deterioration group was lower than the improvement group(P <0.05).Conclusion The early dynamic changes of TBIL,WBC,PT,PTA and INR could reflect the prognosis and guide the treatment of the HBV -ACLF.
Keywords：chronic Hepatitis Bacute -on -chronic liver failurebiochemical index
Publication Date：2016-01-01
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：4( 403-406 )