Effects of X -ray on apoptosis of BGC -803 gastric cancer cell and expression of Survivin protein
Ren Zhentai
Wang Xiaoyu
Abstract：Objective To observe the effects of X -ray on apoptosis of BGC -803 gastric cancer cells and expression of Survivin protein.Methods The BGC -803 gastric cancer cells were divided into control group and experimental groups(radiation doses were 1 、2、5 Gy,respectively).Apoptosis of BGC -803 gastric cancer cells and expression of Survivin protein were detected by flow cytometry.Results The apoptosis rate of BGC -803 cancer cells was increased accompanied by the increase of X -ray dose.The apoptosis rate of BGC -803 cancer cells in 2、5 Gy groups was increased with the passage of time,but there was no chage in 1 Gy group.Low dose(1 、2 Gy)of X -ray had no effect on the expression of Survivin protein,but 5 Gy group had increased the expression.Conclusion The apoptosis of BGC -803 cancer cells was induced by X -ray in a dose -and time -dependent manner.High dose X -ray increased the expressiong of Survivin protein.It may be associated with DNA repair by homologous recombination or cell cycle.
Keywords：gastric cancerX -raysurvivin proteitn
Publication Date：2016-01-01
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：3( 395-397 )