Clinical study on the dosage of dexmedetomidine used for patients after lumbar operation in ICU
Shen Weilin
Zhang Weimin
Nan Xiaosong
Sun Rongqing
Abstract：Objective To investigate the relationship between the adverse reactions and dosage of dexmedetomidine used for patients after lumbar operation in ICU.Methods 1 20 patients with ASA I ~II undergone general anesthesia lumbar decompres-sion and internal fixation operation were selected and randomly divided into three groups:group A treated with intravenous injec-tion of dexmedetomidine with 0.5 μg/kg in 1 0 min,group B with 0.75 μg/kg,group C with 1 .0 μg/kg.The mean artery pres-sure (MAP),heart rate (HR)1 min before intravenous injection of dexmedetomidine was selected as the basic value.Hyperten-sion,hypotension,bradycardia,heartbeat restlessness,nausea and vomiting,excessive sedation,hypoxemia and the incidence of adverse reactions,PCA in 30 min after intravenous injection of dexmedetomidine in three groups were recorded.Results No restlessness,nausea and vomiting occurred in three groups.The incidences of hypertension,numbers of PCA had no significant difference between the three groups.The incidences of hypotension,bradycardia in group B and group C were higher than group A (P <0.05);the incidences of excessive calm and hypoxemia in group B and group C were both 1 5%,with statistical differ-ence compared with group A (P <0.05);all indexes had no statistical difference between group B and group C(P >0.05). Conclusion PCIA combined with 0.5 μg/kg of dexmedetomidine for postoperative analgesia of lumbar internal fixation during ICU can reduce nausea,vomiting,restlessness and cardiovascular adverse reactions,also can reduce the risk of excessive seda-tion and hypoxemia.
Keywords：dexmedetomidinelumbar decompression and internal fixation operationdosage
Publication Date：2016-01-01
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：3( 42-44 )