The diagnostic value of T -SPOT.TB scores in multi -system tuberculosis
Huang Fengxiang
Zhang Hui
Gao Zengyan
Sun Panfeng
Zhao Di
Miao Lijun
Abstract：Objective To evaluate the diagnostic value of T -SPOT.TB scores in multi -system tuberculosis.Methods A retrospective analysis of 530 tuberculosis patients hospitalized from October of 201 3 to September of 201 4 was performed.All pa-tients were tested with T -SPOT.TB assay.The T -SPOT.TB assay yielded values A and B,which represented the number of T cells that were stimulated by the antigens for early secreting antigen target 6 (ESAT -6)or culture filtrate protein -1 0 peptide (CFP -1 0).The patients were divided into single -system and multiple -system group according to the extent of the disease. Independent -samples t tests were used to compare the values A and B between the two groups.Results In 530 patients includ-ed in this study,465 tested positive with a sensitivity of 87.7%.In multi -system groups,the positive rate (94.1 %,1 43 /1 52) was higher than that (85.1 %,322 /378)in single -system groups.The mean A and B values in the multi -system group [(202.32 ±4.57)/1 06 PBMCs and (207.20 ±4.98)/1 06 PBMCs],were significantly greater than those in the single -system group [(35.51 ±2.38)/1 06 PBMCs and (38.48 ±1 .91 )/1 06 PBMCs](tA =5.33,tB =4.48,P <0.001 ).Conclusion T -SPOT.TB score could play an important role in identifying single -system and multi -system tuberculosis infections.Higher score indicates a greater likelihood of multiple -system tuberculosis infection.
Keywords：T -SPOT.TB assayspot foming cell frequencymulti -system tuberculosis
Publication Date：2016-01-01
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：3( 37-39 )