Effects of respiratory support mode on retinopathy of premature infants
Sun Huiqing
Kang Wenqing
Li Mingchao
Xu Bangli
Guo Jing
Liu Dapeng
Xiong Hong
Abstract：Objective To explore the effects of different modes of respiratory support on the occurrence of retinopathy (ROP) and the levels of VEGF and IGF -1 in premature infants.Methods A total of 578 premature infants with gestational age (GA) of 34 weeks or less who had survived from the time of the initial ophthalmologic examination to the final ROP examination were in-cluded in the study.Each infant was categorized as no ROP,stage 1 ,stage 2,more than stage 3 ROP or stage 3 ROP +plus disease.The serum levels of VEGF and IGF -1 were detected at postnatal 1 ,2,3,4 weeks.Results There were 323 infants without ROP,1 26 infants with stage 1 ROP,80 infants with stage 2 ROP,39 infants with ≥stage 3 ROP and 1 0 infants with stage 3 ROP +plus disease.For stage 1 ROP,the incidence was 41 % in mechanical ventilation group which was significantly higher than other groups (P <0.05).For the stage 2 ROP,the incidence of ROP was similar in control group,nasal cannula group,CPAP group,and mechanical ventilation group.But the incidence of ROP in nasal cannula,CPAP and mechanical venti-lation groups together was significantly higher than the control group (P <0.05).The levels of VEGF and IGF -1 at the end of 1 week,2 weeks,3 weeks and 4 weeks were similar between nasal cannula group,CPAP group,and mechanical ventilation groups.Infants receiving respiratory support and controls also had similar VEGF and IGF -1 levels.Conclusion Different modes of respiratory support do not affect the occurrence of more than stage 2 ROP,and also for the levels of VEGF and IGF -1 in premature infants.
Keywords：respiratory supportpremature infantsretinopathy
Publication Date：2016-01-01
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：3( 32-34 )