Detection of serun AFP in patients with Budd -Chiari syndrome complicated by hepatocellular carcinoma and its clinical significance
Yu Miao
Xue Huanzhou
Wang Yadong
ZhangXiao
Abstract：Objective To compare the levels of serun AFP among patients with Budd -Chiari syndrome,hepatocellular car-cinoma,Budd -Chiari syndrome complicated by hepatocellular carcinoma and healthy volunteers,and evaluate the effect of AFP levels in the diagnosis of Budd -Chiari syndrome complicated by hepatocellular carcinoma.Methods From March of 1 998 to March of 201 5,1 98 patients were retrospectively analyzed and divided into three groups:HCC group (n =77),BCS group (n =90)and HCC complicated by HCC group (n =31 ).84 healthy volunteers were selected as control group.The AFP values of dif-ferent groups were analyzed by Software SPSS 1 7.0,and the scatterplot was made by Software GraphPad Prism 5.The receiver -operating characteristic curve (receiver operating characteristic curve,ROC)was drew,and the area under the curve (area under curve,AUC)was calculated.Results ①The difference of AFP values between BCS group and control group was not statistically significant(P >0.05).②AUC of receiver operator charac-teristic curve (ROC)was 0.852.When the cutoff value of AFP was set at 300 ng/ml as the best critical value for the diagnosis of BCS complicated by HCC,the sensitivity,specificity,Youden’s index was 0.80,0.87 and 0.67 respectively.Conclusion The level of AFP in serum is an important index of diagnostic serology for Budd -Chiari syndrome complicated by hepatocellular carcinoma.The efficacy of diagnosis is the best when the cutoff value of AFP was set at 300 ng/ml.
Keywords：Budd -Chiari syndromehepatocellular carcinomaα-fetoproteinReceiver operating characteristic curve
Publication Date：2015-01-01
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：5( 13-16,17 )