0. 5% 5 - flurouracil for the treatment of actinic keratosis:a meta analysis
Zhou Ziguang
Song Yunhuan
Abstract：Objective To assess the effect and safety of 0. 5% 5 - flurouracil in the treatment of Actinic keratosis. Methods The Cochrane library,Medline,Embase,NGC and CBM were searched,the randomized controlled trials(RCTs)about 0. 5%5 - flurouracil for the treatment of actinic keratosis all over the world were included. Two reviewers independently screened the studies for eligibility,evaluated the quality with confirmation by cross - checking. The data were inputted and analyzed by Rev-Man 4. 3 software. Results Three RCT studies involving 528 patients met the inclusion criteria. Meta analysis of the treatment of 0. 5% 5 - flurouracil showed treatment applied once daily for 1,2,or 4 weeks was more effective than vehicle control in lesion clearance. And the treatment for 4 weeks was better than one week and two weeks. Commonly reported adverse events were local-ized facial irritation. Most of them were mild or moderate,and most of these patients were able to tolerate it. Conclusion Topi-cal 0. 5% 5 - flurouracil was an effective and safe regimen for the treatment of actinic keratosis.
Keywords：actinic keratosis5 - flurouracilmeta analysis
Publication Date：2015-01-01
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：3( 14-16 )