Efficacy of rosuvastatin in the prevention of contrast-induced nephropathy in elderly patients with coronary heart disease
Sun Xiaoqiang
Liu Jiyue
Chen Xia
Luo Zhikuan
He Feng
Abstract：Objective To investigate the rosuvastatin in the prevention of contrast-induced nephropathy( CIN)in elderly patients with coronary heart disease. Methods 100 elderly patients with coronary heart disease received coronary angiography were randomly divided into conventional group and rosuvastatin group,50 cases in each group. Rosuvastatin group were given 10 mg rosuvastatin orally,once a day after dinner. The levels of BUN,Scr and Ccr before and 24 hours,72 hours after contrast administration between groups were measured and compared. Results The levels of BUN and Scr in 72 hours after contrast ad-ministration in conventional group were higher than before contrast administration(P﹤0. 05),The levels of Ccr in 72 hours after contrast administration were lower than before contrast administration(P﹤0. 05). The levels of BUN,Scr and Ccr in 24,72 hours after contrast administration did not change in rosuvastatin group(P﹥0. 05). The levels of BUN and Scr after contrast administra-tion in rosuvastatin group were lower than conventional group(P﹤0. 05). The levels of Ccr in rosuvastatin group was higher than conventional group(P﹤0. 05). There was no difference on the incidence of contrast-induced nephropathy between two groups (P﹥0. 05). The incidences of adverse reactions between two groups were not statistically different(P﹥0. 05). Conclusion Ro-suvastatin have a good efficacy in the prevention of contrast-induced nephropathy in elderly patients with coronary heart disease.
Keywords：rosuvastatincontrast-induced nephropathyelderlycoronary heart disease
Publication Date：2015-01-01
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：3( 33-35 )