Relationship between the expression of hypoxia -inducible factor -1α,epidermal growth factor receptor and prognosis in patients with esophageal squamous cell carcinoma
He Chunyu
Hu Xiaona
Wang Wen
Liu Ru
Liu Jinsong
Wu Xiaoyuan
Wang Jianhua
Abstract：Objective To investigate the relationship between the expression of epithelial growth factor receptor(EGFR),hy-poxia -inducible factor -1 α(HIF -1 α)and clinical characteristics and prognosis in esophageal squamous cell carcinoma(ES-CC).Methods 1 1 6 cases of ESCC were analyzed about their clinical pathology and survival data.The expression of HIF -1 α, EGFR were detected by immnohistochemical staining.Results The positive rates of high expression of HIF -1 αand EGFR were 63.8% and 68.1 %.Positive rate of co -expression of HIF -1 αand EGFR was 50.9%.The expression of HIF -1 αwas correlated with T stage(P =0.01 4),and the co -expression was correlated with T and TNM stage (P =0.006,0.023). Spearman rank correlation analysis illustrated that there was a significant correlation between HIF -1 αand EGFR.Kaplan -Meier survival analysis showed that high -expression of EGFR were associated with poor survival.Conclusion HIF -1 αand EGFR played an important role in the development and progression of ESCC,and show intimate relationship with biological be-havior.EGFR may be used as an important index to evaluate the prognosis of esophageal carcinoma.
Keywords：esophageal neoplasmsquamous cell carcinomahypoxia -inducible factor -1 αepithelial growth factor receptorprognosis
Publication Date：2015-01-01
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：4( 1-4 )