Expression and significance of hypoxia -inducible factor -lαand vascular endothelial growth factor -C in esophageal squamous cell carcinoma tissues
Liu Ru
Hu Xiaona
Wang Wen
Liu Jinsong
Wu Xiaoyuan
Wang Jianhua
He Chunyu
Abstract：Objective To investigate the expression of hypoxia -inducible factor -1α(HIF -1α)and vascular endothelial growth factor -c(VEGF -C)in esophageal squamous cell carcinoma(ESCC)tissues and the correlation with the clinicopatholog-ical features.Methods The expression of HIF -1αand VEGF -C in 106 cases of esophageal squamous cell carcinoma tissues and 20 cases of adjacent esophageal mucosa were detected by immunohistochemical staining,and the correlation with clinicopath-ological features were analyzed.Results The positive expression rates of HIF -1αand VEGF -C were higher than adjacent e-sophageal mucosa(P <0.05 ).The expression of HIF -1αwas correlated with T stage (P <0.05 ),and the expression of VEGF -C was correlated with differentiation and lymph metastasis (P <0.05).There was a significantly positive correlation be-tween HIF -1αand VEGF -C protein expression(r =0.331,P =0.000).Conclusion The expression levels of HIF -1αand VEGF -C were higher,and they may play important roles in the development and progression of ESCC.The expression of VEGF -C was correlated with lymph metastasis,and it may be used as an important index to predict the prognosis of ESCC.
Keywords：esophageal neoplasmsquamous cell carcinomahypoxia -inducible factor -1αvascular endothelial growth factor -C
Publication Date：2015-01-01
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：3( 1-3 )