Expression of EGFR,Kras and BRAF in esophageal squamous cell carcinoma tissue and their correlations
He Chunyu
Hu Xiaona
Wang Wen
Liu Ru
Liu Jinsong
Wu Xiaoyuan
Wang Jianhua
Abstract：Objective To investigate the expression of EGFR,Kras and BRAF in esophageal squamous cell carcinoma tissue and their correlation with clinicopathological features.Methods The expression of EGFR,Kras and BRAF in 106 cases of e-sophageal squamous cell carcinoma tissue and 20 cases of adjacent esophageal mucosa were detected by immunohistochemical staining,and the correlations with clinicopathological feature were analyzed.Results The positive rates of EGFR,Kras and BRAF in esophageal squamous cell carcinoma were 70.7%,31.0% and 49.1%.The expression of EGFR and BRAF in esopha-geal carcinoma were higher than adjacent esophageal mucosa(P <0.05),and the expression of Kras in two sorts of tissues showed no statistical difference(P >0.05).The expression of EGFR in esophageal carcinoma was correlated with differentiation, TNMstage and lymph metastasis.In addition,the expression of BRAF were correlated with invasion and TNMstage,but the ex-pression of Kras was not statistically correlated with clinical feature(P >0.05 ).There was a correlation between EGFR and BRAF.Conclusion Overexpression of EGFR and BRAF in esophageal cancer tissues may be correlated with the occurrence and development of esophageal carcinoma.The role of Kras was not clear.EGFR and BRAF may be used as an important index to predict the prognosis of esophageal cancer.
Keywords：esophageal carcinomaimmunohistochemistryepithelial growth factor receptorKrasBRAF
Publication Date：2015-01-01
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：3( 4-6 )