The short -term efficacy of docetaxel combined with xeloda in the treatment of patients with advanced breast cancer
Li Yue
Guo Guangcheng
Zhang Lianping
Abstract：Objective To observe the clinical efficacy and adverse effect of docetaxel combined with xeloda in the treatment of patients with advanced breast cancer after failure of anthracycline -based treatment.Methods Fifty -two patients with ad-vanced breast cancer were treated with docetaxel combined and xeloda.Xeloda 2 500 mg/(m2 ·d),30 min after a meal,twice daily,lasting for fourteen days;docetaxel 75 mg/m2 ivgtt,day 1 ,repeated every three weeks as one cycle.Each patient received 4 cycles chemotherapy at least.The efficacy and side effect were reviewed after chemotherapy.Results There were 7 cases of complete response(CR),27 cases of partial response(PR),8 cases of stable disease(SD)and 1 0 cases of progressive disease (PD),the total effective rate was 65.4%,and tumor control rate was 80.7%.The main adverse effects were hair loss,bone marrow suppression,gastrointestinal reactions,extremities syndrome,skin pigmentation,muscle pain.There was no treatment -related death.Conclusion Docetaxel combined with xeloda was effective in the treatment of patients with advanced breast canc-er after failure of anthracycline -based treatment.The adverse reactions could be tolerated.It is worth clinical promotion and ap-plication.
Keywords：docetaxelxelodaadvanced breast cancer
Publication Date：2015-01-01
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：3( 31-33 )