Impacts of ulinastatin on serum IL -17,HS -CRP,cTnI,beta 2 -MG and MODS of patients with exertional heat stroke

Hu Yuyan; Jiang Hua; Zhang Xiaoming; Zhang Guangbin; Zhao Shuxia; Li Hui

doi:10.3969/j.issn.1004-437X.2015.02.004

Abstract：Objective To investigate the impacts of ulinastatin on serum interleukin -1 7(IL -6),high sense C -reactive protein(HS -CRP),cardiac troponin(cTnI),beta 2 -microglobulin(beta 2 -MG)of patients with exertional heat stroke. Methods ELISA,immunofluorescence dry ration,microparticle enzyme immunoassay,turbidimetric method were used for de-termination of serum IL -1 7,HS -CRP,cTnI,beta 2 -MG levels of 31 cases of EHS additionally treated with ulinastatin(ob-servation group)and 30 cases without ulinastatin treatment(control group)on the second and sixth day of admission,and com-pared with healthy people(normal group).At the same time,the status of multiple organ dysfunction syndrome,involved organs and recovery time in observation and control groups were compared and analyzed.Results No significant difference was observed between control group and observation group in serum IL -1 7,HS -CRP,cTnI,beta 2 -MG level(P >0.05)at the time of ad-mission,but they were significantly higher in observation and control group than normal group(P <0.01 ).On the sixth day of admission,serum IL -1 7,HS -CRP,cTnI,beta 2 -MG in observation group were obviously lower than control group (P <0. 01 ).There was a significant difference in MODS organ involvement rate between the two groups(P >0.05)and the organ recov-ery time in the observation group was significantly shorter(P <0.05).Conclusion By inhibiting the production and release of cytokines and inflammatory mediators,ulinastatin could reduce the damage to the heart and kidney function,reduce EHS organs or systems involved rate,and promote the rapid restoration of affected organs or systems.