Relationship between P wave terminal force in lead V1 and N terminal pro -Brain Natriuretic Peptide in patients with chronic systolic heart failure

Ma Longfei; Zhang Feifei; Qiu Chunguang; Wang Dan; Xie Shiyao

doi:10.3969/j.issn.1004-437X2015.01.005

Abstract：Objective To investigate the relationship between P wave terminal force in lead V1 and N terminal pro -Brain Natriuretic Peptide in patients with chronic systolic heart failure.Methods A total of 80 inpatients diagnosed as chronic systolic heart failure were included in this study.They were divided into 2 groups according to New York Heart Association:(NYHA) Functional Classification Ⅰ、Ⅱ group (n =45),(NYHA)Functional Classification Ⅲ、Ⅳ group (n =35).Control group was consisted of patients hospitalized at the same period without structural heart disease and in normal cardiac functional class (n =22);The P wave terminal force in lead V1 were recorded and the level of NT -ProBNP was measured respectively.Statistical analysis was performed by SPSS 19.0.Results ① The PtfV1 (-0.067 ±-0.023)in chronic systolic heart failure groups were significantly lower than control group (-0.025 ±-0.011)(P <0.05).The NT -ProBNP levels (2 314.21 ±1 465.19)in chronic systolic heart failure groups were significantly higher than control group (78.33 ±14.33)(P <0.05).②The PtfV1 lev-els in different subgroups[NYHA Ⅰ、Ⅱ group (-0.053 ±-0.010)、NYHA Ⅲ、Ⅳ group (-0.086 ±-0.022)]were signifi-cantly lower compared with control group (-0.025 ±-0.011)(P <0.05).The NT -ProBNP levels in different subgroups [(NYHA Ⅰ、Ⅱ group (1 167.15 ±224.46),NYHA Ⅲ、Ⅳ group (3 887.31 ±838.39)]were significantly higher compared with control group (78.33 ±14.33)(P <0.05),and the The PtfV1 decreased but NT -ProBNP level increased with the growing of NYHA functional class (P <0.05).③In correlation analysis,PtfV1 showed significant correlation with plasma NT -ProBNP levels (r =-0.716,P <0.05).Conclusion PtfV1 negative value in patients with chronic systolic heart failure increases and it was closely relative with NT -ProBNP levels,which could act as a practical indicator that reflect the deterioration of cardiac func-tion of patients with chronic systolic heart failure.