The effect of Medilac-s capsule combined with mesalazine on in-flammatory factors in patients with ulcerative colitis
JIN Shuli
LI Zixian
LI Liping
Abstract：Objective:To evaluate the curative effect of Medilac-s capsule combined with mesala-zine and the influence on inflammatory factors in patients with ulcerative colitis. Methods: Two hundred and twenty six cases with active ulcerative colitis were randomly divided into the observa-tion group ( n=114 ) and the control group ( n=112 ) . The observation group were treated with Medilac-s capsule combined with mesalazine while the control group were only treated with mesala-zine. The curative effects in the two groups were compared. And the changes of IL-8, TNF-α,MIF and IL-10 in serum from patients with ulcerative colitis in the two groups were also compared. Results: The total efficiency in the observation group was higher than the control group and the difference was statistically significant ( P<0 . 05 ) . The concentrations of IL-8 , TNF-α, MIF and IL-10 in the two groups were not significantly different before treatment ( P>0 . 05 ) . The concen-trations of IL-8 and TNF-α were more lower in the observation group than the control group ( P<0 . 05 ) , while IL-10 was reverse after treatment ( P <0 . 05 ) . MIF was lower in the observation group than control group, but there was no statistics significance (P>0. 05). The adverse reac-tions in the two group were similar ( P>0 . 05 ) . Conclusion:Medilac-s capsule combined with me-salazine could improve the effective rate in patients with active ulcerative colitis. The two drugs had synergistic effect and could control pathogenetic condition of patients with active ulcerative co-litis. The two drugs have biggish clinical application values and good application prospect.
Keywords：ulcerative colitismesalazineMedilac-s capsuleinflammatory factor
Publication Date：2014-01-01
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：3( 16-18 )