Prognostic value of PCT and Child-Pugh score in patients with HBV-related acute-on-chronic liver failure
SONG Chenyuan
WU Wujia
LV Yuanjun
GUO Zhixian
YU Zujiang
Abstract：Objective:To assess the prognostic value of PCT and the Child-Pugh score in patients with HBV-related acute-on-chronic liver failure,and to evaluate the relationship between PCT and the Child-Pugh score. Methods: The value of PCT and Child-Pugh score of 113 patients with HBV-related acute-on-chronic liver failure were retrospectively calculated. Using Receiver operat-ing characteristic curves to determine PCT and the Child-Pugh score cut-offs with the best sensitivi-ty ( SS) and specificity ( SP) in discriminating between patients who survived and those who died. Results:PCT and Child-Pugh score showed significant correlation ( r=0 . 64 , P<0 . 01 ) . Among the 113 patients PCT and Child-Pugh score of the 29 patients who died were significantly higher than those who survived. According to the ROC curves a Child-Pugh score cut-off of 11. 00 had 69% SS and 73% SP, whereas a PCT cut-off of 2. 66 had 58% SS and 67% SP in discriminating between patients who survived and those who died. The combined assessment of PCT and Child-Pugh score had 89% SS and 77% SP. Conclusion:In patients with HBV-related acute-on-chronic liver failure, the PCT has prognostic capability that is not significantly different from that of Child-Pugh score. Combined assessment of the two parameters increases the prognostic accuracy.
Keywords：hepatitis Bliver failurePCTChild-Pugh scoreprognosis
Publication Date：2014-01-01
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：4( 13-16 )