Expression and clinical significance of tumor suppressor gene Crnn in tissues of esophageal squamous cell carcinoma
BIE Yanan
QIAO Junjing
WANG Jin
ZHANG Zhao
QIN Yanru
Abstract：Objective: To investigate the expression of Crnn in human esophageal squamous cell carcinoma( ESCC) and the role of Crnn in the occurrence, development and prognosis of ESCC. Methods:The expression levels of Crnn in 100 ESCC tissues ( observation group ) were compared with that in corresponding normal esophageal tissues( control group) by immunohistochemical tech-niques. Its correlation with age, gender, tumor-cell differentiation, lymph-node metastasis, TNM stage, general classification and five-year survival rate of ESCC patients were analyzed. Results:The expression rate of Crnn in the observation group was 45 . 6%, which was obviously lower than the control group (93. 7%), the down-regulation rate of Crnn in tumor tissues was 53. 2%, the expression of Crnn gene was correlated with lymph nodes metastasis and TMN stage, but not with age, gender, tumor-cell differentiation and general classification. The five-year survival rate of ES-CC patients with the down expression of Crnn gene was lower than ESCC patients with normal ex-pression of Crnn gene. Conclusion: The down expression of Crnn gene may promote the occur-rence and development of ESCC. Crnn was the candidate tumor suppressor gene of ESCC.
Keywords：Crnn geneesophageal squamous cell carcinomatissue chip
Publication Date：2014-01-01
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：4( 10-13 )