The expression and clinical significance of Survivin and Bax protein in esophageal squamous cell carcinoma
WU Xiaoyuan
HU Xiaona
HE Chunyu
YANG Yuanyuan
HAO Daxuan
LI Xue
WANG Jianhua
Abstract：Objective:To investigate the expression of Survivin and Bax protein in esophageal squa-mous cell carcinoma ( ESCC) tissue and their relations with the clinicopathalogical features and the prognosis. Methods:The expression of Survivin and Bax in 58 cases of ESCC were detected by immnohistochemical staining. Results:The positive rates of Survivin and Bax in ESCC tissue were 77. 6% and 43. 1%, respectively. The positive expression rate of Survivin was correlated with the differentiation (P<0. 05), but not correlated with gender, age, the depth of invasion, lymphatic metastasis, clinical stage, and overall survival time (OS) (P>0. 05). The positive expression rate of Bax was not correlated with gender, age, the depth of invasion, lymphatic metastasis, clini-cal stage, differentiation and OS (P>0. 05). The expression of Survivin was not correlated with Bax ( P>0 . 05 ) . Conclusion: High expression of Survivin protein in ESCC was correlated with the differentiation of cancer cells, It may play an important role in the progression of ESCC.
Keywords：esophageal cancersquamous cell carcinomaSurvivinBaxprognosis
Publication Date：2014-01-01
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：4( 6-9 )