The expressions of DNA-PKcs protein in esophagus cancer and its relationship with clinical pathological characteristics
WANG Kunlun
XU Xiaoxia
ZHANG Zhongxian
LIU Yang
REN Jingli
YUAN Ling
Abstract：Objective:To detect the distribution of DNA-PKcs protein in normal tissue, adjacent tissue, and esophageal cancer tissue and investigate the relationship between the expression of DNA-PKcs protein and clinicalopathological factors of esophagus cancer. Methods:The expression of DNA-PKcs protein was detected by immunohistochemical SP technique in 41 cases of esophagus cancer. Its correlations with gender, age, pathological staging and degree of differentiation were analyzed. Results:The positive rates of DNA-PKcs protein in esophageal cancer tissues, pericarci-noma tissues and normal tissue were 87 . 8%、63 . 4%、51 . 2%. The expression of DNA-PKcs pro-tein in esophageal cancer tissues was significantly higher than that pericarcinoma tissues and nor-mal esophageal tissues ( P<0 . 05 ) . There was no difference between DNA-PKcs protein in esoph-ageal cancer tissues and gender, age, pathological type and staging, but degree of differentiation. Its expression in well-differentiated group was significantly higher than that in poorly-differentiated group ( P<0 . 05 ) . Conclusion:DNA-PKcs protein was obviously different among different tissues and its expression was associated with degree of differentiation. DNA-PKcs protein may be the in-dicator of developing individualized radiotherapy program.
Keywords：DNA-PKcs proteinesophageal cancerimmunohistochemistry
Publication Date：2014-01-01
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：3( 1-3 )