Influence of β-aescine sodium on the serum levels of HS-CRP, TNF-α, IL-17 in patients with MS
ZHANG Xiaoming
LI Hui
ZHAO Shuxia
LI Xinli
WEN Jin
LIU Yan
ZUO Xinyang
Abstract：Objective: To explore the influence of β-aescine sodium on the serum levels of HS-CRP, TNF-α, IL-17 and the quality of life in patients with MS .Methods:Quantitative immuno-cytochemistry and ELISA methods were used to determine the serum levels of HS-CRP, TNF-α, IL-17 in 54 MS patients treated with basic treatment and β-aescine sodium ( observation group ) and 53 MS patients treated without β-aescine sodium ( control group ) before and after treatment . The two groups before and after treatment were evaluated with extended neurological disability scale (EDSS) score respectively.Results:There was no significant difference of the levels of HS-CRP, TNF-α, IL-17 between observation group and control group .All the levels of HS-CRP, TNF-α, IL-17 decreased after treatment ( P<0 .01 ) , but observation group decreased much more than control group ( P<0 .05 ) .There was no significant difference of EDSS scores between observation and control groups before treatment (P>0.05), but EDSS scores of two groups were different after treatment (P<0.05).Conclusion:β-aescine sodium could enhance the effects of hormone on in-hibiting the production and release of HS-CRP, TNF-α, IL-17, further reduce inflammatory reac-tion in patients with MS , and improve the quality of life .
Keywords：multiple sclerosisβ-aescine sodiumhigh sensitivity C reactive proteinextended neurological disability scale
Publication Date：2014-01-01
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：4( 11-13,14 )