Methylation analysis of FHIT and CHFR gene promoter region in colorectal cancers
WANG Yujun
XU Feng
Abstract：Objective:To analyze the methylation level of promoter region of fragile histidine triad ( FHIT) gene and checkpoint with FHA and ring finger ( CHFR) in colorectal cancer and its clini-cal significance.Methods:Methylation Specific PCR (MSP) was used to test methylation patterns of FHIT and CHFR gene in 46 colorectal cancer tissues and corresponding adjacent normal tissues . Results:The methylation rates of FHIT and CHFR were 54 .35%, 49 .15%respectively in color-ectal cancer, which were significantly higher than that in adjacent normal tissues ( 13.04%, 8 .69%) .The methylation status of FHIT and CHFR gene was correlated with differentiation and lymph node metastasis ( P<0 .05 ) , but not associated with age , gender , tumor sites and Dukes Stage(P>0.05).Conclusion: The methylation of promoter region of FHIT and CHFR may be correlated with occurrence , development and prognosis of colorectal cancer .
Keywords：FHIT geneCHFR genemethylationcolorectal cancer
Publication Date：2014-01-01
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：4( 4-7 )