The inhibition of glioma growth by uokinase receptor ligands
BU Xing-yao
KONG Zhong
LI Zuo-ling
ZHANG Feng
ZHANG Yong-fu
Abstract：Objective: To investigate the exact role of urokinase-type plasminogen activator receptor (uPAR) in the development of glioma and the inhibition of glioma growth by uPAR ligands. Methods: A highly reproducible or thotopic brain model has been established in nude mice using the human brain tumor cell line U87MG. Animals xenotransplanted with these tumor cells were treated twice a week subcutaneously with 300 μg/mouse of either mouse or human Peg-uPA 1-48 or a combination of 100 μg of each after the establishment of the tumors. Results: Control animals died within 9 weeks and human Peg-uPA treated animals within 12 weeks from progressive tumor growth. Twenty percent of the mice treated with mouse Peg-uPA and 80% of the mice receiving the combination of both peptides survived over 20 weeks. Histological examination demonstrated a decreased vascularity and tumor cell proliferation, a increased tumor cell apoptosis. Conclusion: uPAR plays a prodominant role in glioma progression. Peg-uPA can effectively inhibit brain glioma growth and might prove to be useful for adjuvant treatment of brain glioma.
Keywords：urokinase receptorbrain gliomaangiogenesisadhesionapoptosisdhesion
Publication Date：2006-01-01
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：9( 1-9 )