Effects of polysaccharide sulfate on ionic currents in guinea pig ventricular myocytes
Abstract：Objective: To examine the effects of polysaccharide sulfate (PSS) on ionic currents in guinea pig ventricular myocytes. Methods: Single ventricular cells of guinea pigs were isolated with a collagenase(I-type) dispersion method, using whole-cell recording method to record L-type Ca2 + current(Ica,L) and the inward rectifier K + current( IK1 ). Results:the inward component but also the outward component of the peak Ik1, PSS decreased the time constant of activation of IK1 and PSS increased the maximal slope conductance of IK1. Conclusion: PSS decreases L-type Ca2 + current, increases the inward rectifier K + current.
Keywords：polysaccharideventricular myocytesthe patch-clamp techniqueL-type Ca2+ currentthe inward rectifier K+ current
Publication Date：2004-01-01
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：5( 203-207 )