A study of correlation of p16 protein in prostatic carcinoma and dysplasia
Abstract：Objective： To study the expression of p16 gene in prostatic carcinoma and dysplasia.Methods：Immunohistochemistry (S-P） assay was carried out,im munohistochemical detection of p16 protein in 70 cases prostatic carcinoma,10 ca ses normal prostatic tissues and 20 cases prostatic hyperplasia,40 cases prostat ic dysplasia and 30 cases prostatic dysplasia adjacent to prostatic carcinoma.Results：31 cases showed positive staining of p16 protein (45% ) in 70 cases prostatic carcinoma,all cases showed positive staining of p16 prot ein in 10 cases normal prostatic tissues and 20 cases prostatic hyperplasia.28 cases showed postive staining of p16 protein(70%) in 40 cases prostatic dysplasi a.21 cases showed positive staining of p16 protein(70%) in 30 cases prostatic dysplasia adjacent to prostatic carcinoma, the expression level of p16 protein in prostatic carcinoma is markedly lower than that of dysplasia and prostatic dyspla sia adjacent to prostatic carcinoma. Conclusion: p16 gene play an important role in carcinogenesis and development of prostatic.
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Publication Date：2001-01-01
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：3( 109-111 )