Expression and correlation of HPV16、18E6 and HPV16 E7 proteins in laryngeal squamous cell carcinoma
Abstract：Objective: To investigate relation of HPV16、18E6 and HPV16E7 proteins with carcinogenesis of laryngeal squamous cell carcinoma and correlation between E6 and E7 proteins.Methods: The expression of E6 and E7 proteins were examined by immunohistochemistry method in 58 cases of laryngeal cancers. Results: In laryngeal cancar and paracancerous tissuse,the positive rates of E6 were 31.0%(18/58) and 20.0(6/30);the positive rates of E7 were 32.7%(19/58) and 20.3%(7/30).E6 and E7 were negative in polyp of vocal cord.There were significant differences between cancer group and polyp of vocal cord group,cancer with cervical lymphnode metastasis group and no metastasis group(P＜0．01）．There was correlation between E6 and E7.Conclusion: It suggests that infection of HPV16、18 is closely related to the carcinogenesis of largngeal cancer.E6 and E7 proteins have the synergism in the carcinogenesis and development of laryngeal cancer.
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Publication Date：2001-01-01
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：3( 26-27 )