Influence of bovine acidic neuropeptide 1 on some neurotransmitters of amino acids and cGMP in mouse brain
Abstract：Objective： The aim of the research is to probe the changes of some neurotransmitters of amino acid (glutamic acid,Glu)and (γ-aminobutyric acid,GABA)and cGMP in mice brains caused by bovine acidic neuropeptide 1(BANP-1）．Methods: Mice were separated into six groups (n=15 at each group).Five of the groups were injected with BANP 1 into mice's abdominal cavities at dose of 15 mg/kg and brain was collected and homogenated at 0.5 h，1 h,2 h,3 h and 4 h for examination.The other group was injected with normal saline as control group and brain was collected at 1 h for examination.Brain Glu and GABA were analysised by filter paper-electrophoresis method.Brain cGMP were analysised by radiation immunity method.Results： After injection of BANP-1 in 1 h, 2 h,3 h,4 h,the results were compared with that of control group.It indicated that:Glu concentration had a significant increase in 1 h,2 h(P＜0.01，P＜0.01 respectively).GABA also increased in 2 h,3 h(P＜0.01 respectively).cGMP concentration increased in 1 h，2 h(P＜0.05，P＜0.01 respectively)．Conclusion: After injection of BANP-1，the concentrations of Glu and GABA and cGMP increased at different time.
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Publication Date：2001-01-01
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：3( 14-16 )