Changes and significance of neuropeptide in the aged rats with gastrointestinal injury after brain ischemia reperfusion
Abstract：Objective： To study the mechanism of gastrointestinal injury after brain ischemia reperfusion in aged rats from the changes of endotheliolysin(ET),calcitonin gene relationed peptide(CGRP),NT. Methods： Young(5 months)and aged (20 months or more)rats were divided into young model group(YMG),young control group(YCG),aged model group(AMG),aged control group(ACG).The following items were measured in rats with 60-minute reperfusion after 30-minute brain ischemia:the level of ET,CGRP,and NT in plasma as well as the morphological changes of gastrointestinal tract. Results： Pathological change of gastrointestinal tract was found distinctly in the YMG and the AMG,this change was seriously in the aged rats than that in the young rats.The plasma CGRP and NT level in the YCG was higher than that in the YMG and the ACG.The ET content was higher in the AMG than that in the ACG and the YMG. Conclusion: The gastrointestinal injury after brain ischemia reperfusion was correlated with the NT decrease and the dysequilibrium between CGRP and ET in which ET was dominant.But because the change of ET,CGRP and NT with aging,these pathological changes had distinctive characteristics in aged rats with brain ischemia compared with that in the young rats.
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Publication Date：2001-01-01
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：3( 8-10 )