The correlation between expression of bcl-2 protein and prognosis indicator in breast carcinoma
Abstract：Objective: To study the expression of bcl-2 protein in breast carcinoma and benign breast hyperplasia. To observethe relationship between bcl-2 protein expression and prognostic indicators of breast carcinoma. Methods: 69 cases of invasivebreast carcinoma,45 cases of ductal carcinoma in situ (DCIS) ,38 cases benign hyperplasia and 15 cases normal breast tissuewere studied for the expression of bcl-2 protein by means of immunohistochemistry. Results: The expression of bcl-2 protein ininvasive breast carcinoma,DCIS,benign hyperplasia and normal breast tissue were 65.2% ,75.6%, 100% and 100%. Bcl-2protein expression is associated with a number of favorable prognosis factors, such as small rumor size, low histologic grade, ERand PR positivity, less necrosis(P＜0.01) and low p53 protein(P＜0.05). It was found that the status of axillary lymph nodeinvasion didn' t correlate with the expression of bcl-2 protein (P＞0.05). Bcl-2+/p53-phenotype was expressed in mostlybreast carcinoma, it was seen almost in cases of well-differentiated and intermediately-differentiated. Bcl-2 +/p53- phe notypewas consistently expressed in normal breast tissue, benign hyperplasia. Conclusion: ①Bcl-2 protein expression has been foundto higher in normal breast epithelium and benign breast proliferative lesions than in breast carcinoma. ② A relationship hasbeen reported between bcl-2 protein expression and good prognosis factors. ③Immunohistochemical detection of bcl-2 protein isrelated in versely to p53 protein expression.
Keywords：breast carcinomabcl-2 proteinp53 proteinhyperplasiaimmunohistoche mistry
Publication Date：2000-01-01
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：3( 308-310 )