Effect of pH in action of ligustrazine on the electrophysiological and mechnical properties in guinea pig papillary muscles
Bai Qin
KONG Xu-li
Abstract：Objective: The experiment studied the effects of pH in action of ligustrazine on the electrophysiological and me-chanical properties in guinea pig papillary muscles. Methods: The electrophysiological method, the standard glass microelec-trode technology. Results: It was found ① adjusting not pH and adjusting pH to 7.4 ligustrazine ( 3.0～30μmol/L) sup-pressed the action potential amplitude (APA) the action potential duration(APD). The maximal upstroke velocity Vmax of SAPinduced by histamine and force of contraction (FC) dose-dependently. ②adjusting pH to 7.4 ligustrazine (0.1～3.0mmol/L) increas APA,APD,Vmax and FC dose-dependently, adjusting not pH ligustrazine (0.1～3.0 mmol/L) suppressed APA,APD, Vmax and FC. Conclusion: These results suggested. ①ligustrazine have dual effects on myocardiun. ②pH effect action ofligustrazine on the electrophysiulogical and mechanical properties in guinea pig papillary muscles.
Keywords：pHligustrazineaction potentialfore of contraction
Publication Date：2000-01-01
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：3( 298-299,303 )