A study on the relationship between p53 gene mutation and lymph node metastasis of hmnan esophageal carcinoma
YAN Ming
ZHANG Hong-xin
ZHANG Qian
Abstract：Objective: To discuss the relationship between p53 gene mutation and lymph node metastasis of human esophagealcarcinoma. Methods: PCR-SSCP methods and silver staining technique were used to analyse the mutations of p53 gene exons5～8 in 47 cases of esophageal carcinoma samples. Results: Mutation in exons 5～8 of the p53 gene were found in 20 casesout of 47 patients with esophageal carcinoma. The total mutation rate was 42.6%(20/47).Mutation of p53 gene were detected13 of 22 cases with lymph node metastasis(59.1%, 13/22). The incidence of mutation of p53 gene in the cases of lymph nodemetastasis was obviously higher than that in patients without metastasis (28.0% ,7/25)( P＜0.05). Conclusion: These re-sults suggest that p53 gene mutation were related to metastasis of human esophageal carcinoma.
Keywords：esophageal carcinomap53 genemutationmetastasisPCR-SSGP
Publication Date：2000-01-01
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：2( 296-297 )