Mutations of K-ras gene in lung cancer
Abstract：Objective: To detect the relation of K-ras gene the development of lung cancer. Methods: We used PCR-SSCPmethods and silver stainingtechnique to analyse the mutations of the 12,13,61 codes of K-ras gene in 32 cases lung cancersamples. and their normal tissues around these cancer samples. Results: Mutations of K-ras gene were 8 cases mutation positivewhich yielded a total mutation rate of 25%(8/32) ,Mutation of K-ras gene were detected in 4 of 10(40% ) adenocarcinomascell carcinomas,3 of 13(23% ) squamous cell carcinomas, 1 of 3(33% ) big cell lung carcinomas. Condusion: K-ras genemutation was a common event in lung cancer which plays an important role during lung cancer.
Keywords：lung cancerK-ras genepolymerase chain reaction-single strand conformation polymorphism
Publication Date：2000-01-01
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：3( 134-136 )